The Curious Case of Capsaicin & Substance P
What if the secret to understanding chronic pain lies in a single molecule? Let’s unravel the mysteries of Substance P and its role in your body.
What if the secret to understanding chronic pain lies in a single molecule?
Let’s unravel the mysteries of Substance P and its role in your body.
When I started developing the Curse Lifter gummy, I was diving deep into nutraceutical compounds that might work well with CBD and CBG. For years, I had experimented with resveratrol, quercetin, magnesium, and other plant compounds that I knew paired beautifully with cannabinoids.
I knew I wanted to create a spicy CBG + CBD gummy that had depth, potency, and delivered the best possible effects. But there was one big problem: when we combined all these "beneficial" ingredients, the taste was awful!
Even with the perfect blend of hot chili, I began to worry my ambitious gummy might be a total flop. Then I remembered something: Capsaicin has a lot of potential therapeutic benefits that aren’t fully understood yet. I’ve been studying capsaicin’s topical effects for nearly a decade. Could it have positive effects in an edible form?
While I had researched capsaicin for years, it hadn’t been a focus since 2018 when I formulated the first batch of Restorative Body Balm. Within minutes of diving back into my research, I stumbled on something remarkable: Capsaicin and Magnesium may help the body reset the brain’s release of Substance P and flush it out of our bodies.
What is Substance P?
Substance P is a neuropeptide that contributes to inflammation in the brain and nervous system. Substance P activates stress-processing pathways in the brain.
This can lead to defensive changes in the cardiovascular, respiratory, gastrointestinal, and psychological systems.
When there’s too much Substance P in the body, it may lead to a range of issues, including:
Convulsions and nervous system disorders
Chronic discomfort and fatigue
Histamine response (like allergies)
Depression, anxiety, and serotonin deficiency
How Can We Reset Substance P?
Here’s what I found:
Deep Sleep helps reset the brain’s release of Substance P. Unfortunately, conditions that disrupt sleep make it harder for the body to heal itself.
Magnesium and Capsaicin may help the body balance out the release of Substance P. Magnesium deficiency may be related to why our brains start producing too much substance P in the first place.
Major Hemp Cannabinoids may help in metabolizing antioxidants, flushing free radicals, and promoting deeper sleep.
The Evidence & Current Research
Substance P (SP) and Its Role in Seizures: Research shows that Substance P is involved in emotional behavior, anxiety, pain, and inflammation. The linked study suggests SP may also increase the risk of seizures.
Intrathecal Capsaicin and Pain Relief: Studies in rats demonstrated that Capsaicin could reduce Substance P in sensory neurons, leading to prolonged relief.
Substance P Causes Seizures in Tapeworm Infections: A study found that Substance P can trigger seizures in patients infected by pork tapeworm.
These abstracts are just scratching the surface of research.
But we can infer that a lot can wrong in our bodies if the production of Substance P is out of whack.
By utilizing capsaicin, cannabinoids, and magnesium both internally and topically, I have changed my life for the better in so many ways.
With consistent use of products like the CURSE LIFTER gummies, Berry Balsam gummies as well as the Fire & Ice Salve I hope to build systems that help people get their life back the same way I have worked through my degenerative Dis-Ease.
Please Let me know if you find anything interesting about Substance P on your journey!
May your wellness be eternal,
Drew Gremillion